Comodo anti-virus software falsely identifies and quarantines ck2.exe (the main game file) as infected. If ck2.exe is not present in the CK2 directory this is the problem, you will get a JIT (Just-in-time) error as seen in this thread. You will have to rescue ck2.exe from quarantine back to where it belongs, and flag it and ck2game.exe with Comodo as trusted Files.
Comodo anti-virus detects CK2.exe as infected/malicious
